Delta-9 THC is the cannabinoid most associated with the classic “high” of cannabis. It is the most studied, most widely known cannabinoid on the planet. Delta-9 THC has unique psychoactivity and has been shown to be a powerful anti-inflammatory, anti-nociceptive, and antioxidant.
CBD is the second most studied cannabinoid. It is known for its many beneficial qualities, such as combating inflammation, potentially helping to reduce seizures, and acting as an analgesic. CBD is nonpsychoactive. For most people, CBD produces experiences associated with relaxation and calmness.
CBDa is the acidic form of CBD. CBDa produces effects similar to CBD that are associated with promoting relaxation and calmness and acting as an anti-inflammatory agent and an analgesic. CBDa effects the body’s endocannabinoid system (ECS) differently than CBD. CBDa inhibits the cyclooxygenase-2 (COX-2) enzyme where CBD binds directly to CB1 and CB2 receptors.
THCa is the acidic form of THC. When energy is applied, the molecule loses CO2 and is transformed into THC’s neutral form. THCa is mildly psychoactive in higher doses. Preliminary investigation indicates THCa may be effective in pain management, have antiemetic properties, and display neuroprotective properties.
Delta-8 THC is produced from delta-9 THC. It has about half of delta-9’s psychoactivity and tends to be more relaxing and uplifting. Delta-8 may help to attenuate pain and reduce stress and anxiety. According to clinical studies in Israel, delta-8 THC has demonstrated powerful antiemetic and anti-nausea properties.
CBG is the progenitor cannabinoid to all other cannabinoids. It is produced in only minor amounts. CBG is nonpsychoactive and has been shown to help reduce anxiety and act as an anti-inflammatory agent.
THCV is a member of the varin class of cannabinoids. THCV is the first cannabinoid to display appetite-reducing properties. Mildly psychoactive, THCV is purported to have energetic qualities—helping to stimulate and focus the mind.
CBN is a mildly psychoactive cannabinoid formed as a result of the degradation of THC. CBN is often described as a mild analgesic and potential sleep aid.